The Regional Genomic Practitioner Service
Comprehensive genomic sequencing offers patients with cancer the possibility of receiving a more precise diagnosis at the start of their treatment pathway. This can provide prognostic information and guide faster access to precision treatments or surgical intervention. Knowledge of a patients complete genomic profile helps to avoid drug toxicities and enables access to molecularly stratified clinical trials. Equally important, it may also identify at risk family members who may be eligible for risk stratification and cancer prevention strategies.
Adoption of genomics into cancer care needs a clinical workforce with understanding of how and where genomic testing fits into current clinical pathways and how to use it.
The Genomic Clinical Practitioners are working across the East of England Cancer Alliances geography to deliver the genomics agenda. The Genomic Clinical Practitioners will work with the three Genomic Medical Service Alliances and their associated Genomic Laboratory Hubs that map into the East of England Cancer Alliance Geography, ensuring that relationships are built with the Medical Genetics Services that align to all localities. The service will facilitate, support and engage with primary and secondary care colleagues to develop pathways and embed genomic testing and/or advice for all service users in cancer care.
The Cancer Alliance Regional Genomic Service is dedicated to supporting healthcare professionals across the East of England. However, we are unable to provide direct medical advice or engage with patients regarding their personal care. If you have questions about your treatment, we encourage you to speak with your healthcare team, who are best placed to guide and support you.
Contact the Regional Genomic Clinical Practitioner Service on:
cpicb.eoegenomicsteam@nhs.net
All emails will be directed to the correct practitioner for your area.
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BRCA |
Breast Poster / Flowchart / PowerPoint |
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Colorectal Poster / Somatic testing flowchart / Germline testing flowchart / PowerPoint |
Cancer of Unknown Primary (CUP) |
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DPYD |
Family History |
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Genomic Champion |
Genomics vs Genetics and National Test Directory |
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GMSA and GLH |
Gynaecological Poster / Endometrial flowchart / Ovarian flowchart / PowerPoint |
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Informed consent in Genomics |
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Lynch Syndrome Poster / Colorectal flowchart / Endometrial flowchart / PowerPoint / Germline testing guide |
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Prostate |
Upper GI Poster / Flowchart / Oesophageal somatic testing flowchart / Genomic testing in Pancreatic cancer flowchart / OG PowerPoint / Pancreatic PowerPoint |
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What is Genomics? |
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The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Join the thousands of healthcare staff using the QGenome app
Clinicians across the East Midlands and East of England can now have genomic referral, risk assessment and testing guidance in the palm of their hand, thanks to an NHSE-funded app called QGenome. The app, which can be downloaded for iOS and Android devices (with a web-based version also available) is based on national guidelines including NHS England’s National Genomic Test Directory. The app currently supports clinicians in the areas of cancer, cardiology, renal, prenatal and primary care. Some feedback from clinicians currently using the app includes:
- “Incredibly useful. Feels like I have a Genetic Counsellor on my shoulder.”
- “For someone new to genomics it has been invaluable in understanding eligibility pathways and has improved my knowledge and ability to speak to patients about their concerns.”
- “User friendly. Great educational and clinical decision support tool.”
You can find out more, including how to download the app on the QGenome website.
To watch a demo of the app by Dr Anju Kulkarni (one of the creators), please click here.
| Important concepts in cancer cell biology and genetics - Training Science Communicated Ltd | |
| Session 1 - Cancer cell biology | P1 - Click here to watch |
| Session 2 - Targeted therapies | |
| Session 3 - Immunotherapy | P2 - Click here to watch |
| Session 4 - Precision cancer medicine | |
To access the October 2024 Regional Clinical Genomic Practitioner Webinar click here.
Genomics in Primary Care Webinar - May 2025, can be viewed here.
| September 2024 Newsletter | December 2024 Newsletter | |
| June 2025 Newsletter |
If you are a healthcare professional and would like to sign up to our newsletter, please email: cpicb.eoegenomicsteam@nhs.net
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BRCA |
EUROPAC |
Family History |
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Genomics vs Genetics and National Test Directory |
GMSA and GLH |
Jewish BRCA Testing Programme Information sheet / Jewish BRCA testing – Jnetics / The NHS Jewish BRCA Testing Programme - Jewish BRCA |
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Lynch Syndrome Poster / Colorectal flowchart / Endometrial flowchart / PowerPoint |
What is Genomics? |
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| NHS East Genomics Lynch Syndrome UK app | ||
| Lynch Syndrome: should I take aspirin to reduce my chance of getting bowel cancer? | The Role of Genomics in Primary Care - GatewayC free course | Results from the Cancer Prevention Project 3 trial | Bowel Cancer UK |
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
NICE (CG104), 2023. Available at: https://www.nice.org.uk/guidance/cg104/ (accessed June 2025)
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Cancer of Unknown Primary (CUP) |
Whole Genome Sequencing for suspected cancer - Information for patients and family members |
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Communities of Practice
East Genomics are supporting 16 Genomics Communities of Practice to support healthcare staff across specialities and job roles to share best practice, upskill and better integrate genomic medicine into their clinical practice.
For cancer these include:
Urology / Lung / CUP / Paediatric, teenage & young adult haemato-oncology / Pancreatic / Haemato-oncology / Gynaecological Oncology.
This link will take you to view each of the Communities of Practice including who is leading it, a schedule of upcoming meetings, how to join, and where to access slides and recordings from previous meetings
https://www.eastgenomics.nhs.uk/for-healthcare-professionals/east-genomics-communities-of-practice/
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Colorectal Poster / Somatic testing flowchart / Germline testing flowchart / PowerPoint |
Gynaecological |
Lynch Syndrome |
| Genetic testing for Lynch Syndrome :: East of England Cancer Alliance | NHS East Genomics Lynch Syndrome app |
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
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BRCA |
Breast Poster / Flowchart / PowerPoint |
Gynaecological |
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Prostate |
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The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
| NHS England - Cancer Vaccine Launch Pad |
The NHS England Cancer Vaccine Launch Pad (CVLP) is a platform facilitating access to clinical trials of cancer vaccines, with the aim to accelerate the development of cancer vaccines and increase the opportunity for patients to take part in cancer vaccine trials. The CVLP is being set up in a phased approach to support multiple industry partners with new cancer vaccines across a broad range of cancer types, this started with a focus on patients with colorectal cancer.
The opportunity to be a recruitment centre for the Cancer Vaccine Launch Pad study in Colorectal Cancers is now closed. In the East Of England Cancer Alliance we had 5 Hospital sites participate, those being Ipswich, Colchester, Milton Keynes, MSE and Cambridge.
The Cancer Vaccine Launch Pad (CVLP) study, is now supporting a cancer vaccine trial in unresectable recurrent/unresectable metastatic Head and Neck Squamous Cell Carcinoma (HNSCC). This is a research project and so to activate as a CVLP site Trusts would need their R&D department to issue confirmation of capacity and capability (C&C)
The Head & Neck BNT113-01 is a phase II randomised control trial to compare BNT113-01 in combination with pembrolizumab versus pembrolizumab monotherapy as a first line therapy in patients with unresectable recurrent or unresectable metastatic HNSCC that is positive for HPV16 and expresses PD-L1. As part of the BNT113-01 study, patients will be centrally tested for HPV16 DNA and PD-L1 with results returned within 7-10 working days, which may be quicker than local testing and may help reduce the burden on your local testing facilities. We hope that in the East of England our 4 tertiary centres will be taking part: Norwich, Cambridge, Luton and Mid & South Essex.
