The Regional Genomic Practitioner Service
Comprehensive genomic sequencing offers patients with cancer the possibility of receiving a more precise diagnosis at the start of their treatment pathway. This can provide prognostic information and guide faster access to precision treatments or surgical intervention. Knowledge of a patients complete genomic profile helps to avoid drug toxicities and enables access to molecularly stratified clinical trials. Equally important, it may also identify at risk family members who may be eligible for risk stratification and cancer prevention strategies.
Adoption of genomics into cancer care needs a clinical workforce with understanding of how and where genomic testing fits into current clinical pathways and how to use it.
The Genomic Clinical Practitioners are working across the East of England Cancer Alliances geography to deliver the genomics agenda. The Genomic Clinical Practitioners will work with the three Genomic Medical Service Alliances and their associated Genomic Laboratory Hubs that map into the East of England Cancer Alliance Geography, ensuring that relationships are built with the Medical Genetics Services that align to all localities. The service will facilitate, support and engage with primary and secondary care colleagues to develop pathways and embed genomic testing and/or advice for all service users in cancer care.
The Cancer Alliance Regional Genomic Service is dedicated to supporting healthcare professionals across the East of England. However, we are unable to provide direct medical advice or engage with patients regarding their personal care. If you have questions about your treatment, we encourage you to speak with your healthcare team, who are best placed to guide and support you.
Contact the Regional Genomic Clinical Practitioner Service on:
cpicb.eoegenomicsteam@nhs.net
All emails will be directed to the correct practitioner for your area.
BRCA
Breast
Poster / Flowchart / PowerPoint
Colorectal
Poster / Somatic testing flowchart / Germline testing flowchart / PowerPoint
Cancer of Unknown Primary (CUP)
Poster / Flowchart / PowerPoint
DPYD
Family History
Genomic Champion
Genomics vs Genetics and National Test Directory
GMSA and GLH
Gynaecological
Poster / Endometrial flowchart / Ovarian flowchart / PowerPoint
Informed consent in Genomics
Lynch Syndrome
Poster / Colorectal flowchart / Endometrial flowchart / PowerPoint / Germline testing guide
Prostate
Poster / Flowchart / R430 Prostate germline testing poster
Upper GI
Poster / Flowchart / Oesophageal somatic testing flowchart / Genomic testing in Pancreatic cancer flowchart / OG PowerPoint / Pancreatic PowerPoint
What is Genomics?
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
NHS England Genomics Education Programme
Genomics 101 Genomics in Healthcare
Genomics and Couselling Skills
Future Learn - A Clinician's Guide to Genomic Testing for Cancer (Solid Tumours)
NHS Learning Hub - Introduction to Immune Checkpoint Inhibitors
GeNotes: Genomic notes for clinicians
Join the thousands of healthcare staff using the QGenome app
Clinicians across the East Midlands and East of England can now have genomic referral, risk assessment and testing guidance in the palm of their hand, thanks to an NHSE-funded app called QGenome. The app, which can be downloaded for iOS and Android devices (with a web-based version also available) is based on national guidelines including NHS England’s National Genomic Test Directory. The app currently supports clinicians in the areas of cancer, cardiology, renal, prenatal and primary care. Some feedback from clinicians currently using the app includes:
- “Incredibly useful. Feels like I have a Genetic Counsellor on my shoulder.”
- “For someone new to genomics it has been invaluable in understanding eligibility pathways and has improved my knowledge and ability to speak to patients about their concerns.”
- “User friendly. Great educational and clinical decision support tool.”
You can find out more, including how to download the app on the QGenome website.
To watch a demo of the app by Dr Anju Kulkarni (one of the creators), please click here.
Important concepts in cancer cell biology and genetics - Training Science Communicated Ltd
Session 1 - Cancer cell biology
Session 2 - Targeted therapies
Session 3 - Immunotherapy
Session 4 - Precision cancer medicine
P1 (Includes session 1 & 2) - Click here to watch
P2 (Includes session 3 & 4) - Click here to watch
To access the October 2024 Regional Clinical Genomic Practitioner Webinar click here.
Genomics in Primary Care Webinar - May 2025, can be viewed here.
If you are a healthcare professional and would like to sign up to our newsletter, please email: cpicb.eoegenomicsteam@nhs.net
BRCA
EUROPAC
Family History
Genomics vs Genetics and National Test Directory
GMSA and GLH
Jewish BRCA Testing Programme
Information sheet / Jewish BRCA testing – Jnetics / The NHS Jewish BRCA Testing Programme - Jewish BRCA
Lynch Syndrome
Poster / Colorectal flowchart / Endometrial flowchart / PowerPoint
What is Genomics?
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Genomics in Primary Care Webinar - May 2025
Lynch Syndrome quick guide for Primary Care clinicians
Lynch Syndrome e-learning for Primary Care practitioners
NHS East Genomics Lynch Syndrome UK app
Lynch Syndrome: should I take aspirin to reduce my chance of getting bowel cancer?
The Role of Genomics in Primary Care - GatewayC free course
Results from the Cancer Prevention Project 3 trial | Bowel Cancer UK
BRCA
Breast
Poster / Flowchart / PowerPoint
DPYD
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Macmillan Genomics Toolkit - Breast
Interim ESR1 Genomic Sample Routing Pathway - East Genomic Medicine Service
ESR1 Breast ctDNA Testing Education Session - North Thames Genomic Medicine Service
The Royal Marsden - A beginner's guide to BRCA1 and BRCA2
Breast cancer ESR1 ctDNA testing FAQ Document – North Thames GMSA
BRCA
Gynaecological
Poster / Endometrial flowchart / Ovarian flowchart / PowerPoint
Lynch Syndrome
Poster / Endometrial flowchart / PowerPoint / Germline testing guide
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Macmillan Genomics Toolkit - Gynae
The Royal Marsden - A beginner's guide to BRCA1 and BRCA2
Genetic testing for Lynch Syndrome :: East of England Cancer Alliance
NHS East Genomics Lynch Syndrome app
Results from the Cancer Prevention Project 3 trial | Bowel Cancer UK
Colorectal
Poster / Somatic testing flowchart / Germline testing flowchart / PowerPoint
DPYD
Lynch Syndrome
Poster / Colorectal flowchart / Endometrial flowchart / PowerPoint / Germline testing guide
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
NHS East Genomics Lynch Syndrome app
Macmillan Genomics Toolkit - Colorectal
Genetic testing for Lynch Syndrome :: East of England Cancer Alliance
Lynch Syndrome: should I take aspirin to reduce my chance of getting bowel cancer?
Lynch Syndrome quick guide for Primary Care clinicians
Results from the Cancer Prevention Project 3 trial | Bowel Cancer UK
DPYD
Upper GI
Poster / Flowchart / Oesophageal somatic testing flowchart / Genomic testing in Pancreatic cancer flowchart / OG PowerPoint / Pancreatic PowerPoint
EUROPAC
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Macmillan Genomics Toolkit - Lung
North Thames Genomics - ctDNA project explained
North Thames Genomics – circulating tumour DNA
East Genomics - Circulating Tumour DNA (ctDNA)
East Genomics - Phase III ctDNA Lung Cancer Program Overview
East GMSA - ctDNA Lung Cancer Pilot Phase III Performance Data April '24-March '25
NICE (CG104), 2023. Available at: https://www.nice.org.uk/guidance/cg104/ (accessed June 2025)
Whole Genome Sequencing for suspected cancer - Information for patients and family members
Cancer of Unknown Primary (CUP)
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
East Genomics Cancer and genetics patient leaflet
East Genomics Clinician's Guide to Genomic Testing
East Genomics Letter - Improving efficiency and appropriateness of genomic test referrals
Discussing Germline Testing: A 10-Step Clinic Guide
Communities of Practice
East Genomics are supporting 16 Genomics Communities of Practice to support healthcare staff across specialities and job roles to share best practice, upskill and better integrate genomic medicine into their clinical practice.
For cancer these include:
Urology / Lung / CUP / Paediatric, teenage & young adult haemato-oncology / Pancreatic / Haemato-oncology / Gynaecological Oncology.
This link will take you to view each of the Communities of Practice including who is leading it, a schedule of upcoming meetings, how to join, and where to access slides and recordings from previous meetings
https://www.eastgenomics.nhs.uk/for-healthcare-professionals/east-genomics-communities-of-practice/
Colorectal
Poster / Somatic testing flowchart / Germline testing flowchart / PowerPoint
Gynaecological
Poster / Endometrial flowchart / PowerPoint
Lynch Syndrome
Poster / PowerPoint / Germline testing guide
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
Genetic testing for Lynch Syndrome :: East of England Cancer Alliance
BRCA
Breast
Poster / Flowchart / PowerPoint
Gynaecological
Poster / Ovarian flowchart / PowerPoint
Prostate
Poster / Flowchart / R430 Prostate germline testing poster
The PowerPoint presentations have been uploaded in PDF format. If you would prefer the PowerPoint version, please request this and we will provide this for you to use / edit.
NHS England - Cancer Vaccine Launch Pad
The NHS England Cancer Vaccine Launch Pad (CVLP) is a platform facilitating access to clinical trials of cancer vaccines, with the aim to accelerate the development of cancer vaccines and increase the opportunity for patients to take part in cancer vaccine trials. The CVLP is being set up in a phased approach to support multiple industry partners with new cancer vaccines across a broad range of cancer types, this started with a focus on patients with colorectal cancer.
The opportunity to be a recruitment centre for the Cancer Vaccine Launch Pad study in Colorectal Cancers is now closed. In the East Of England Cancer Alliance we had 5 Hospital sites participate, those being Ipswich, Colchester, Milton Keynes, MSE and Cambridge.
The Cancer Vaccine Launch Pad (CVLP) study, is now supporting a cancer vaccine trial in unresectable recurrent/unresectable metastatic Head and Neck Squamous Cell Carcinoma (HNSCC). This is a research project and so to activate as a CVLP site Trusts would need their R&D department to issue confirmation of capacity and capability (C&C)
The Head & Neck BNT113-01 is a phase II randomised control trial to compare BNT113-01 in combination with pembrolizumab versus pembrolizumab monotherapy as a first line therapy in patients with unresectable recurrent or unresectable metastatic HNSCC that is positive for HPV16 and expresses PD-L1. As part of the BNT113-01 study, patients will be centrally tested for HPV16 DNA and PD-L1 with results returned within 7-10 working days, which may be quicker than local testing and may help reduce the burden on your local testing facilities. We hope that in the East of England our 4 tertiary centres will be taking part: Norwich, Cambridge, Luton and Mid & South Essex.
